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Does Borderzone Contrast Enhancement on Intraoperative MRI During High Grade Glioma Resection Correlate With Residual Tumor?


N/A
18 Years
N/A
Not Enrolling
Both
High Grade Glioma, Glioblastoma

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Trial Information

Does Borderzone Contrast Enhancement on Intraoperative MRI During High Grade Glioma Resection Correlate With Residual Tumor?


Inclusion Criteria:



- supratentorial brain tumor, on contrast enhanced MRI suspect for a high grade glioma

- indication for resection of the tumor

- age ≥ 18 years

- WHO Performance Scale ≤ 2

- ASA class ≤ 3

- good knowledge of the Dutch language

- informed consent

Exclusion Criteria:

- recurrent tumor

- multiple tumor localizations

- prior radiotherapy on the skull

- prior chemotherapy

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

The relation between the shape and size of contrast enhancement on intraoperative MRI at the resection cavity border, and the presence of residual tumor tissue.

Outcome Time Frame:

after surgery, and after 1 year for additional immunochemistry

Safety Issue:

Yes

Principal Investigator

Pieter L Kubben, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Maastricht University Medical Center

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

MEC 07-2-039

NCT ID:

NCT00780819

Start Date:

October 2008

Completion Date:

December 2012

Related Keywords:

  • High Grade Glioma
  • Glioblastoma
  • Glioblastoma
  • Glioma

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