Inclusion Criteria:

- adult patients, >= 18 years of age;

- non-squamous non-small cell lung cancer, locally advanced and unresectable;

- ECOG performance status 0 or 1;

- no prior thoracic or head and neck radiation;

- no prior surgical resection for current lung cancer.

Exclusion Criteria:

- malignancies other than non-small cell lung cancer within 2 years prior to inclusion,
except for basal cell cancer of the skin, squamous cancer of the skin, or cancer in
situ of the cervix;

- prior systemic therapy for non-small cell lung cancer;

- clinically significant cardiovascular disease;

- history of >= grade 2 hemoptysis;

- current or recent use of aspirin (>325mg/day) or full dose anticoagulants or
thrombolytic agents for therapeutic purposes.