MRI - Guided Biopsy for Suspicion of Locally Recurrent Prostate Cancer After External Beam Radiotherapy
This study involves the technical development and clinical testing of a novel technique for
magnetic resonance imaging (MRI) guided prostate biopsy in a 1.5T horizontal bore scanner
using a dedicated interventional table. We primarily hypothesize that the integration of
diagnostic and interventional MRI enables needle biopsy targeting to foci of tumor
recurrence after radiotherapy, and will enable a determination of the diagnostic accuracy of
MRI in mapping sub-sites of tumor recurrence after radiotherapy. RELEVANCE TO PUBLIC
HEALTH: Patients with recurrence of their prostate cancer after radiotherapy currently face
difficult choices. Standard second line treatments target the entire prostate gland and are
associated many side effects. This study will directly improve the detection, spatial
delineation, and characterization of prostate cancer persistence after radiotherapy. If
anatomic patterns of disease persistence are found across patients, radiation delivery
techniques will be suitably modified, which may translate to improved cure rates.
Importantly, this study will establish a procedural platform for MRI-guidance of minimally
invasive local salvage therapies. By precisely focusing salvage therapy to sites of tumor
persistence within the prostate gland, side effects may be reduced in the future.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
The primary endpoint is a preliminary estimate of the diagnostic accuracy of MRI in identifying sites of recurrent tumor after radiotherapy for prostate cancer.
at the end of the evaluation phase
Cynthia Ménard, MD
University Health Network, Toronto
Canada: Ethics Review Committee
UHN REB 05-0641-C