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Surveillance of the Cohort of Patients Overexposed in a Course of Conformational Radiotherapy for a Prostate Adenocarcinoma in Jean MONNET Hospital, Epinal, France. Epinal: Patients Overexposed for a Prostate Adenocarcinoma


N/A
18 Years
N/A
Open (Enrolling)
Male
Prostate Adenocarcinoma

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Trial Information

Surveillance of the Cohort of Patients Overexposed in a Course of Conformational Radiotherapy for a Prostate Adenocarcinoma in Jean MONNET Hospital, Epinal, France. Epinal: Patients Overexposed for a Prostate Adenocarcinoma


Secondary study endpoint:

- Correlation between adverse events and radiation doses with biologic, phenotypic and
genetic data.

- Evaluation of T-lymphocyte apoptosis to predict radiation-induced late toxicity

- Gene associations with risks for adverse events related to radiotherapy

- Levels of circulating microparticles and bystander effect after irradiation

Inclusion criteria:

Consecutive patients treated for a prostate adenocarcinoma in the radiation department of
the Jean MONNET Hospital between 2000 and 2006.

Potential. Better identification of patients at high risk of adverse events related to
radiotherapy.


Inclusion Criteria:



- provision of informed consent

- patient treated for prostate adenocarcinoma and overexposed during radiotherapy in a
prostate adenocarcinoma in the radiation department of the a prostate adenocarcinoma
in the radiation department of the Jean MONNET hospital/ service de radiotherapies
between 2000 and 2006

Exclusion Criteria:

- No provision of informed consent

- Patient with disease worsening and in incapacity to move about to CHJM

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Outcome Measure:

To correlate the received doses, the volume of irradiated normal tissues, the events, with biologic, phenotypic and genetic data.

Outcome Time Frame:

At the inclusion visit

Safety Issue:

No

Principal Investigator

Jean Marc SIMON, PH

Investigator Role:

Principal Investigator

Investigator Affiliation:

Assistance Publique - Hôpitaux de Paris

Authority:

France: Ministry of Health

Study ID:

AOM 08234

NCT ID:

NCT00773656

Start Date:

October 2008

Completion Date:

December 2015

Related Keywords:

  • Prostate Adenocarcinoma
  • Radiotherapy
  • Biologically effective dose
  • Radiation injury
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Prostatic Neoplasms

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