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Chart Review of the Efficacy of Prostate Seed Implantation for Local Control of Early Stage Prostate Cancer

18 Years
80 Years
Not Enrolling
Prostate Cancer

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Trial Information

Chart Review of the Efficacy of Prostate Seed Implantation for Local Control of Early Stage Prostate Cancer

Charts of early stage prostate cancer patients receiving prostate seed implants with or
without external beam radiotherapy and/or hormonal therapy will be reviewed and abstracted.
The abstracted data will include pathology reports including Gleason score and T stage, PSA,
treatment assignment and dosimetry parameters including dose and percent compliant with
established criteria based on guidelines established by the American Brachytherapy Society.

A database will be developed for capture of the abstracted data. Outcomes will be
determined based on PSA levels at 2 and 5 years after prostate seed implantation. The role
of hormonal therapy with prostate seed implantation and outcomes will be evaluated. The
outcomes will be compared to national statistics.

Inclusion Criteria:

- Prostate seed implantation for the treatment of early stage prostate cancer

Type of Study:


Study Design:

Observational Model: Ecologic or Community, Time Perspective: Retrospective

Outcome Measure:

To determine the efficacy of prostate brachytherapy for local control of early stage prostate cancer at Summa Health System

Outcome Description:

A retrospective chart review of PSA values on 85 patients from 2001-2008 with prostate cancer stage T1c-T2a NX MO, who were treated with permanent prostate brachytherapy using conventional transrectal ultrasound guided placement of Iodine-125 seeds delivering 145 Gy or 110 Gy, depending on whether mono or combination therapy with external beam radiotherapy (EBRT) was used. Those who had EBRT received 45 Gy prior to seed implants. Some patients also received hormonal therapy.

Outcome Time Frame:

Pre-op through 4 follow-up visits

Safety Issue:


Principal Investigator

William Demas, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Summa Health System


United States: Institutional Review Board

Study ID:

Prostate Seed Implantation



Start Date:

October 2008

Completion Date:

October 2012

Related Keywords:

  • Prostate Cancer
  • seed implantation
  • Prostatic Neoplasms