Trial Information

The Impact of Lymphedema on Local and Overall Functioning

OBJECTIVES:

- To determine the relationship between degree of lymphedema, lymphedema-associated
symptoms, and local upper extremity functioning.

- To determine the relationship between degree of lymphedema, lymphedema-associated
symptoms, local upper extremity functioning, and overall health-related functioning.

- To determine the relationship between degree of lymphedema, lymphedema-associated
symptoms, local upper extremity functioning, overall health-related functioning, and
quality of life.

OUTLINE: Patients are stratified according to presence of lymphedema (yes vs no).

Patients complete self-reporting questionnaires to assess the degree of lymphedema using the
Norman Questionnaire and Jane M. Armer's Lymphedema and Breast Cancer Questionnaire;
lymphedema-associated symptoms using Symptoms in the Affected Breast/Mastectomy site
questionnaire, Symptoms in the Shoulder, Arm, or Hand on the Affected Side questionnaire,
and General Symptom Experience questionnaire; local upper extremity functioning using hand
dominance questionnaire and the Disabilities of the Arm, Shoulder, and Hand (DASH)
questionnaire; quality of life (QOL) using the Multidimensional QOL Scale; and comorbidity
using the Charleston Comorbidity Scale. Patients undergo a 3.5-hour testing to assess the
degree of lymphedema by arm circumference and bioimpedance spectroscopy (BIS); local upper
extremity functioning by strength testing, range of movement and neurodynamic testing using
a goniometer, a skin examination, skin sensation and sensation at scar using the
Semmes-Weinstein Monofilament test, and fine motor control/finger coordination using the
Purdue Pegboard, Finger Tapper, and Vibration Threshold; and overall health-related
functioning using a graded exercise test.