Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma
Heat shock protein 70 (HSP 70) may be involved in various aspects of immune system including
infection, autoimmunity, and tumor immunity. The relationship between HSP70 expression,
disease activity and cancer prognosis varied according to type of cancer. The overexpression
of HSP70 by tumor cells contributes to tumor behavior. HSP70 is present in normal and
abnormal hepatocytes, and was reported to be over-expressed in both hepatoma cell lines and
human hepatocellular carcinoma (HCC) tissue. Recent study indicated that HSP70 is a
molecular marker during early hepatocarcinogenesis. It is also involved in anti-tumor
immunity in HCC.We also investigate the polymorphism of tumor necrosis factor-alpha
promoter, and correlated to clinical relevance.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Jung-Fa Tsai, M.D., Ph.D.
Professor of Medicine
Taiwan: Department of Health