Treatment of Advanced Bulky Malignancies With Spatially Fractioned Radiation Therapy A Phase II Randomized Trial
This study will evaluate response to radiation therapy by a large bulky tumor is influenced
by adding a single dose of 15 Gy grid radiotherapy. To accomplish this, patients with large
bulky tumors in the lung, abdomen or pelvis will be randomized to receive either standard
palliative radiation or palliative radiation plus a single fraction of grid radiation.
Tumor response, pain relief and duration of response, and pain control will be monitored.
Toxicity of treatment will also be followed. The hypothesis of this study is that grid
radiation will produce a significant improvement in tumor response and pain control that
produces no further increase in acute or late toxicity.
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
To demonstrate that grid radiation can be given safely at Summa Health System Hospitals complication to patients undergoing palliative radiation of massive tumors.
during duration of treatment of 3 weeks. Follow up exams every 6 months for the next two years and then yearly for the rest of your life.
Michael Seider, Ph.D., M.D.
Summa Health System
United States: Institutional Review Board
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