Inclusion Criteria:

1. Patients with recurrence of prostate cancer following radical prostatectomy for
prostate adenocarcinoma

2. Patients with initially undetectable PSA following prostatectomy for prostate
adenocarcinoma with subsequent PSA relapse

3. Patients being planned for radiation therapy

4. Patient is being planned for implant with Calypso Transponders in the prostate bed

5. No evidence of distant metastases

6. Age ≥ 18 years

7. Informed consent

Exclusion Criteria:

1. The patient has received other investigational therapy in the last 60 days

2. The patient has previously been implanted with permanent beacon transponders

3. The patient has a prosthetic implant in the pelvic region that contain metal or
conductive materials

4. The patient has any other medical or other condition that would, in the
investigator's opinion, make them a poor candidate for the study