Inclusion Criteria:

- Patient has operable stage I-IIIa breast cancer of the following subtypes: (1)
ER-negative, PR-negative, and HER2-negative breast cancer; (2) ER-positive tumor
meeting one of the following criteria- histologic grade 3; histologic grade 2 and
PR-negative; histologic grade 2 and Ki67> 10%. Tumor is at least 2 cm in diameter as
assessed by physical or radiographic exam

- Patient is female and > 18 years of age

Exclusion Criteria:

- Patient is pregnant, breastfeeding or planning to become pregnant while in the study

- Patient has received prior chemotherapy, biological therapy or radiation

- Patient has participated in a clinical trial in the last 30 days

- Patient has a history of drug or alcohol abuse in the last year

- Patient is HIV positive. Patient has a history of Hepatitis B or C

- Patient has poorly controlled diabetes mellitus.