A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Prostate Cancer in East Anglia, Trent and West Midlands
- To obtain epidemiological information and biological material on a population-based
series of prostate cancer cases.
- To identify novel cancer susceptibility genes by comparison of genotype frequencies in
cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition
- To evaluate interactions between polymorphisms in predisposition genes and potential
lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire, including information on
education, occupation, smoking habits, alcohol consumption, height, weight, family history
of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples and
from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL as well
as from additional controls through the European Prospective Investigation of Cancer (EPIC)
study (a population based study of diet and health based in Norfolk, East Anglia). DNA
samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the prostate cancer patients recruited for this study, patients with breast,
ovarian, endometrial, colorectal, bladder, kidney, pancreatic, brain and esophageal cancer,
malignant melanoma, and lymphoma cancer are recruited in the following related clinical
trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL,
MREC-SEARCH-COLORECTAL, and MREC-SEARCH-CANCER.
Acquisition of epidemiological information and biological material
Paul Pharoah, MD
Cancer Research UK