A Population Based Control Collection for Genetic Studies in East Anglia
- To obtain blood samples and simple epidemiological information on a population-based
series of adult individuals without cancer.
- To establish whether polymorphisms in putative cancer predisposition genes are
associated with an increased risk of cancer by comparing the frequency of alterations
in these genes with the corresponding frequency in a comparable series of cancer
- To examine the interactions between genetic and non-genetic risk factors.
OUTLINE: This is a multicenter study.
Participants complete a simple epidemiological questionnaire.
Participants undergo blood sample collection. DNA is extracted from these samples for
polymorphism analysis of low penetrance cancer susceptibility genes in the following related
clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may
also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN,
PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for
Acquisition of blood samples and epidemiological information
Paul Pharoah, MD
Cancer Research UK