A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands
- To obtain epidemiological information and biological material on a population-based
series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney,
esophageal, and pancreatic cancer, and brain tumors.
- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in
cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition
- To evaluate interactions between polymorphisms in predisposition genes and potential
lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire that includes information on
education, occupation, smoking habits, alcohol consumption, height, weight, reproductive
history (age at menarche, age at pregnancies, parity, and age at menopause), oral
contraceptive use, hormone replacement therapy use, family history of cancer, and past
Blood samples are collected from patients. DNA is extracted from these blood samples, from
samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from
additional controls through the European Prospective Investigation of Cancer (EPIC) study (a
population-based study of diet and health based in Norfolk, East Anglia). DNA samples are
analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the cancer patients recruited for this study, patients with breast, ovarian,
endometrial, colorectal, and prostate cancer are recruited for the following related
clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL,
MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.
Acquisition of epidemiological information and biological material
Paul Pharoah, MD
Cancer Research UK