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A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands


N/A
18 Years
69 Years
Open (Enrolling)
Both
Bladder Cancer, Brain and Central Nervous System Tumors, Esophageal Cancer, Intraocular Melanoma, Kidney Cancer, Lymphoma, Melanoma (Skin), Pancreatic Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter

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Trial Information

A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands


OBJECTIVES:

- To obtain epidemiological information and biological material on a population-based
series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney,
esophageal, and pancreatic cancer, and brain tumors.

- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in
cases with the corresponding frequencies in large control series.

- To estimate the age and sex-specific risks associated with variants in predisposition
genes.

- To evaluate interactions between polymorphisms in predisposition genes and potential
lifestyle risk factors.

OUTLINE: This is a multicenter study.

Patients complete a detailed epidemiological questionnaire that includes information on
education, occupation, smoking habits, alcohol consumption, height, weight, reproductive
history (age at menarche, age at pregnancies, parity, and age at menopause), oral
contraceptive use, hormone replacement therapy use, family history of cancer, and past
medical history.

Blood samples are collected from patients. DNA is extracted from these blood samples, from
samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from
additional controls through the European Prospective Investigation of Cancer (EPIC) study (a
population-based study of diet and health based in Norfolk, East Anglia). DNA samples are
analyzed for polymorphisms of low penetrance cancer susceptibility genes.

In addition to the cancer patients recruited for this study, patients with breast, ovarian,
endometrial, colorectal, and prostate cancer are recruited for the following related
clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL,
MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer,
brain cancer, malignant melanoma, or lymphoma within the past 5 years

- Identified through the Cancer Research Network OR through the cancer registry serving
any of the following geographic regions of the United Kingdom:

- East Anglia

- West Midlands

- Trent

PATIENT CHARACTERISTICS:

- Identified by the patient's general practitioner as fit to contact for this study

- No serious mental illness or retardation

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Acquisition of epidemiological information and biological material

Safety Issue:

No

Principal Investigator

Paul Pharoah, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Cancer Research UK

Authority:

Unspecified

Study ID:

CDR0000598879

NCT ID:

NCT00757614

Start Date:

February 2008

Completion Date:

Related Keywords:

  • Bladder Cancer
  • Brain and Central Nervous System Tumors
  • Esophageal Cancer
  • Intraocular Melanoma
  • Kidney Cancer
  • Lymphoma
  • Melanoma (Skin)
  • Pancreatic Cancer
  • Transitional Cell Cancer of the Renal Pelvis and Ureter
  • AIDS-related lymphoma
  • cutaneous lymphoma
  • adult Hodgkin lymphoma
  • adult non-Hodgkin lymphoma
  • intraocular lymphoma
  • adult T-cell leukemia/lymphoma
  • primary central nervous system non-Hodgkin lymphoma
  • primary central nervous system Hodgkin lymphoma
  • noncutaneous extranodal lymphoma
  • adult astrocytic tumors
  • adult brain stem glioma
  • adult choroid plexus tumor
  • adult craniopharyngioma
  • adult embryonal tumor
  • adult ependymal tumors
  • adult meningeal tumor
  • adult oligodendroglial tumors
  • adult pineal parenchymal tumor
  • adult brain tumor
  • intraocular melanoma
  • bladder cancer
  • clear cell sarcoma of the kidney
  • congenital mesoblastic nephroma
  • esophageal cancer
  • melanoma
  • pancreatic cancer
  • peripheral primitive neuroectodermal tumor of the kidney
  • renal cell carcinoma
  • rhabdoid tumor of the kidney
  • transitional cell cancer of the renal pelvis and ureter
  • Urinary Bladder Neoplasms
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Esophageal Diseases
  • Esophageal Neoplasms
  • Lymphoma
  • Melanoma
  • Nervous System Neoplasms
  • Pancreatic Neoplasms
  • Central Nervous System Neoplasms
  • Uveal Neoplasms
  • Carcinoma, Transitional Cell
  • Ureteral Neoplasms

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