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A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Breast Cancer in East Anglia


N/A
18 Years
70 Years
Open (Enrolling)
Both
Breast Cancer

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Trial Information

A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Breast Cancer in East Anglia


OBJECTIVES:

- To obtain epidemiological information and biological material on a population-based
series of breast cancer cases.

- To establish whether polymorphisms in putative cancer predisposition genes are
associated with an increased risk of breast cancer by comparing the frequency of
alterations in breast cancer patients with the corresponding frequency in controls.

- To define the proportion of breast cancer incidence attributable to mutations in such
genes.

- To examine the interactions between genetic and nongenetic risk factors.

- To evaluate the relationship between pathological and clinical characteristics of
breast cancers and germline genotype.

OUTLINE: This is a multicenter study.

Patients complete an epidemiological questionnaire that covers standard known breast cancer
risk factors including reproductive history, oral contraceptive use, hormone replacement
therapy use, family history, and alcohol consumption. The questionnaire will also request
identifying information on the patient's first-degree relatives.

Blood samples are collected from patients. DNA is extracted from these blood samples, from
samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from
additional controls through the European Prospective Investigation of Cancer (EPIC) study (a
population-based study of diet and health based in Norfolk, East Anglia). DNA samples are
analyzed for polymorphisms of low penetrance cancer susceptibility genes.

In addition to the breast cancer patients recruited for this study, patients with malignant
melanoma and lymphoma, colorectal, ovarian, prostate, colorectal, bladder, kidney,
pancreatic, and esophageal cancer, and brain tumors are recruited for the following related
clinical trials: MREC-SEARCH-COLORECTAL, MREC-SEARCH-OVARIAN, MREC-SEARCH-PROSTATE,
MREC-SEARCH-ENDOMETRIAL, and MREC-SEARCH-CANCER.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of breast cancer within the past 5 years

- Identified through the East Anglian Cancer Registry in the East Anglia region of the
United Kingdom

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- Identified by the patient's general practitioner as fit to contact for this study

- No serious mental illness or retardation

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Acquisition of epidemiological information and biological material

Safety Issue:

No

Principal Investigator

Paul Pharoah, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Cancer Research UK

Authority:

Unspecified

Study ID:

CDR0000598878

NCT ID:

NCT00757211

Start Date:

February 2008

Completion Date:

Related Keywords:

  • Breast Cancer
  • breast cancer
  • male breast cancer
  • Breast Neoplasms

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