Compromised Microcirculation in Women With Polycystic Ovary Syndrome
18 Years
35 Years
Female
Polycystic Ovary Syndrome
Trial Information
Compromised Microcirculation in Women With Polycystic Ovary Syndrome
In these studies, we propose to use the skin as a relatively non-invasive model to examine
cardiovascular and endothelial function in obese women with and without PCOS. Data have
indicated an important role for testosterone in influencing the peripheral microcirculation.
While testosterone can lead to vasodilation in the peripheral microcirculation in both men
and in women without PCOS, testosterone appears to induce vasoconstriction in women with
PCOS. The differential response between women with and without PCOS, and between men and
women may be the result of differential ET-1 actions in the vessel, and regulated by the
receptor subtype is involved in these actions.
Inclusion Criteria:
- Obese women (18-35) years with and without PCOS
Exclusion Criteria:
- Conditions that would preclude safe use of hormones
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Outcome Measure:
Skin blood flow and cutaneous vascular conductance
Outcome Time Frame:
6 non consecutive days
Safety Issue:
No
Principal Investigator
Nina Stachenfeld, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
John B. Pierce Laboratory
Authority:
United States: Institutional Review Board
Study ID:
0801003437
NCT ID:
NCT00757185
Start Date:
February 2008
Completion Date:
December 2012
Related Keywords:
- Polycystic Ovary Syndrome
- skin blood flow
- microcirculation
- Polycystic Ovary Syndrome
Name | Location |
|---|---|
| John B. Pierce Laboratory | New Haven, Connecticut 06520 |
