Compromised Microcirculation in Women With Polycystic Ovary Syndrome
In these studies, we propose to use the skin as a relatively non-invasive model to examine
cardiovascular and endothelial function in obese women with and without PCOS. Data have
indicated an important role for testosterone in influencing the peripheral microcirculation.
While testosterone can lead to vasodilation in the peripheral microcirculation in both men
and in women without PCOS, testosterone appears to induce vasoconstriction in women with
PCOS. The differential response between women with and without PCOS, and between men and
women may be the result of differential ET-1 actions in the vessel, and regulated by the
receptor subtype is involved in these actions.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Skin blood flow and cutaneous vascular conductance
6 non consecutive days
Nina Stachenfeld, PhD
John B. Pierce Laboratory
United States: Institutional Review Board
|John B. Pierce Laboratory||New Haven, Connecticut 06520|