Inclusion Criteria:

Subjects must meet all of the inclusion criteria outlined below in order to be eligible to
participate in this study:

1. Adult subjects (aged 18 to 55 years old) undergoing or scheduled to undergo
myeloablative conditioning and allogeneic BMT, or stem cells from matched donors.

2. Subjects using either busulfan or total body irradiation (TBI) containing regimens
for BMT for the treatment of malignant and nonmalignant diseases. For example:

- Cyclophosphamide and Total Body Irradiation (CY-TBI) with a TBI dose of at least
1200 cGy of fractionated TBI

- Etoposide and Total Body Irradiation (VP16-TBI) with a TBI dose of at least 1200
cGy of fractionated TBI

- Busulfan and cyclophosphamide (BU-CY) with at least 14 mg/kg busulfan orally or
11.2 mg/kg busulfan intravenously (14 x 0.8 correction factor) or a targeted
busulfan dosing strategy aimed at a serum concentration greater than 600 ng/mL
at steady state.

3. Leukemia patients with:

- acute myelogenous leukemia (AML)

- acute lymphoblastic leukemia (ALL) in first or subsequent complete remission

- chronic myelogenous leukemia (CML) in first or subsequent chronic phase or in
accelerated phase

- myelodysplastic syndrome (MDS) patients.

OR

Subjects with non-Hodgkin's lymphoma who are in complete remission as determined by
physical exam, CT and PET scans, and are otherwise considered candidates for
allogeneic BMT as judged by the treating institution

4. Available matched related CD34+ stem cells (target cell dose between 2 x 10^6/kg and
10 x 10^6/kg (actual body weight)) for transplantation (matched at 6/6 HLA at Class I
HLA-A and B and Class II HLA-DRBI).

5. Sex distribution: men or nonpregnant women. Women of childbearing potential must
have a negative serum β-human chorionic gonadotropin (hCG) or urine assay prior to
eritoran treatment or prior to the beginning of conditioning treatment. Menopausal
women must have been amenorrheic for at least 12 months.

6. Race: any.

7. Has signed informed consent before any study-specific procedures are performed.

Exclusion Criteria:

1. Unwilling or unable to agree to be fully evaluated for all follow-up visits. The
subject or subject's representative and the study staff should agree to perform all
study assessments even if the subject is discharged from the hospital.

2. Seropositive for human immunodeficiency virus (HIV); testing is not needed if already
performed (documentation required) as part of screening for conditioning treatment.

3. Subjects with a documented or possible systemic infection, or suspected of having a
medically significant viral, bacterial, or fungal infection at the beginning of
treatment on Day -3.

4. Have taken any investigational medications (ie, not approved by the FDA for any
indication) within the 30-day period prior to enrollment into the study.

5. Karnofsky Performance Status (KPS) <60%.

6. Have previously received a bone marrow or stem cell transplant.

7. Are to receive T-cell depleted BMT or stem cell infusions.

8. Are pregnant or lactating.

9. Known sensitivity to eritoran or its excipients.

10. Prior malignancies treated with a curative intent of < 5 years will not be allowed.
Previously treated cancer with a curative intent of > 5 years will be allowed.

11. Legal incapacity.

12. Any of the following laboratory parameters within 2 days prior to the beginning of
treatment on Day -3:

- direct bilirubin ≥ 2x ULN

- liver function tests (ALT or AST) with values ≥ 3x ULN

- serum creatinine ≥ 2x ULN

13. Subjects who are enrolled in other interventional, investigational protocols. As
aGvHD is likely to only occur after treatment with eritoran is completed,
investigational treatments for Grades III and IV aGvHD may be allowed and should be
discussed with the Sponsor.

14. Subjects with a history of or with current pulmonary disease with forced vital
capacity (FVC) or forced expiratory volume in 1 second (FEV1) < 60% predicted
(corrected for hemoglobin).

15. Subjects with a history of a cardiac ejection fraction < 45%, or with marked
screening or baseline prolongation QT/QTc interval (QTc interval > 470 mSec).