Randomized Phase II Study of Combination Chemotherapy With Sildenafil Plus Carboplatin and Weekly Paclitaxel in Patients With Previously Untreated Advanced Non-small Cell Lung Cancer
Sildenafil is one of selective phosphodiesterase type 5 inhibitors. It is used to block the
degradative action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells
lining the blood vessels, which leads to smooth muscle relaxation in blood vessels and
increases blood flow. Because phosphodiesterase type 5 is also present in the arterial wall
smooth muscle within the lungs, phosphodiesterase type 5 inhibitors is also used for the
treatment of pulmonary hypertension.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
progression free survival
three-year
Yes
Kingo Chida, MD,PhD
Study Chair
Hamamatsu University School of Medicien Institution Review Board
Japan: Institutional Review Board
Hamamatsu 18-66
NCT00752115
February 2007
December 2010
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