Early Detection of Lung Cancer - A Pan Canadian Study
- To develop a new multi-modal screening strategy and integrated methods to detect lung
cancer early in current and former smokers.
- To evaluate the impact of the screening modalities on the quality of life of these
- To develop a decision analytic framework for determining the cost and effectiveness of
a novel lung cancer screening strategy in Canada.
OUTLINE: This is a multicenter study.
Participants undergo spirometry at baseline. Participants also undergo spiral CT scan at
baseline and then at 1 and 2 years. Participants with semi-solid or solid nodules of 5-10 mm
or ground glass opacity (GGO) 8-10 mm or those with growth of an existing nodule,
development of a solid component in GGO, or a new nodule undergo an additional CT scan at 3
months. Some participants also undergo autofluorescence and white light bronchoscopy and
Blood samples are collected at baseline and then annually for 2 years for biomarker studies.
Participants diagnosed with lung cancer undergo additional blood sample collection for
Participants complete questionnaires on sociodemographic factors, smoking, occupational
exposure, family history, medical data, quality of life, and anxiety at baseline and then
every 6 months for up to 2 years.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
Number of lung cancer cases detected early by spiral CT scan and autofluorescence bronchoscopy
Stephen Lam, MD
British Columbia Cancer Agency
Canada: Ethics Review Committee