Inclusion Criteria:

- Diagnosis of radiation retinopathy

- History of choroidal melanoma status post plaque brachytherapy

- Age > 21 years

- Ability to perform written consent and comply with study assessments for the full
duration of the study

Exclusion Criteria:

- Pregnancy or lactation, pre-menopausal women not using contraception

- Participation in another simultaneous medical investigation or trial

- Patient with significantly compromised visual acuity in the study eye due to
concomitant ocular conditions.

- Patients who have undergone intraocular surgery within last 60 days.

- Patients who have had intravitreal anti-VEGF treatment within 45 days.

- Patients who have had intravitreal triamcinolone acetonide within 4 months.

- Patients who have had laser within 60 days.

- Inability to obtain photographs to document CNV (including difficulty with venous
access).

- Patient has a history of any medical condition which would preclude scheduled visits
or completion of study.

- Aphakia or absence of the posterior capsule in the study eye. Previous violation of
the posterior capsule in the study eye is also excluded unless as a result of yttrium
aluminum garnet (YAG) posterior capsulotomy in association with posterior chamber
lens implantation..

- History of glaucoma filtering surgery in the study eye.

- Concurrent use of more than two therapies for glaucoma.

- Any other condition that the investigator believes would pose a significant hazard to
the subject if the investigational therapy were initiated