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Investigating Absorbed Radiation Dose Delivered to Differentiated Thyroid Cancer Metastases Following Administration of Fixed Activity of Radioactive Iodine


N/A
18 Years
N/A
Open (Enrolling)
Both
Thyroid Carcinoma, Metastatic Sites Lung Bone Nodal

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Trial Information

Investigating Absorbed Radiation Dose Delivered to Differentiated Thyroid Cancer Metastases Following Administration of Fixed Activity of Radioactive Iodine


Study Design - the assessment of patients with multiple tumour sites with metastatic thyroid
cancer to correlate the administered activity to absorbed dose. Patients will receive the
standard therapy dose of 5.5 GBq as per the hospital policy and there will be no change for
the protocol purpose.


Inclusion Criteria:



- age above 18

- histological confirmation of the differentiated thyroid carcinoma available

- WHO performance score 0-2

- metastatic sites lung and/or bone and/or nodal (radiologically measurable disease > 1
cm)

- life expectancy > 6 months

- patient has undergone total/near total thyroidectomy

- no past history of sensitivity/reaction to 1311

Exclusion Criteria:

- non iodine concentrating tumours

- received chemotherapy or radiotherapy in 6 weeks

- pregnant or breast feeding patients

- iodine contrast injection in last 3 months

Type of Study:

Interventional

Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

The primary outcome measure is to correlate the predicted dose from the tracer study with the actual absorbed dose measure on the therapeutic scan

Principal Investigator

Dr Kate Newbold

Investigator Role:

Principal Investigator

Investigator Affiliation:

Royal Marsden NHS Foundation Trust

Authority:

United Kingdom: Research Ethics Committee

Study ID:

CCR3047

NCT ID:

NCT00749697

Start Date:

May 2008

Completion Date:

July 2010

Related Keywords:

  • Thyroid Carcinoma
  • Metastatic Sites Lung Bone Nodal
  • radioiodine
  • differentiated thyroid cancers
  • dosimetry
  • metastases
  • Carcinoma
  • Thyroid Neoplasms
  • Neoplasm Metastasis
  • Thyroid Diseases

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