T2* Cardiac MRI Screening of Highly Transfused Patients With Myelodysplastic Syndrome
N/A
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Both
Myelodysplastic Syndrome (MDS)
Both
Myelodysplastic Syndrome (MDS)
Trial Information
T2* Cardiac MRI Screening of Highly Transfused Patients With Myelodysplastic Syndrome
Inclusion Criteria:
- Male or Female patients will need documentation of diagnosis of Myelodysplastic
Syndrome by previous bone marrow exam
- Male or female patients with MDS who have received at least 50 units of Red Blood
Cell Transfusions.
- Serum ferritin > 1,000
- Written informed consent by the patient.
Exclusion Criteria:
- Contraindication to MRI, including cardiac pacemaker, brain aneurysm clip, implanted
neurostimulator, insulin pump, cochlear implant, metal slivers in the eyes,
intrauterine device or any other MRI incompatible metal implants or intractable
claustrophobia.
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
Outcome Measure:
To evaluate the incidence of clinically significant cardiac iron overload in heavily transfused MDS patients using T2* MRI.
Outcome Time Frame:
A single T2* MRI will be performed on eligible patients.
Safety Issue:
No
Principal Investigator
Eric Feldman, M.D.
Investigator Role:
Principal Investigator
Investigator Affiliation:
Weill Medical College of Cornell University
Authority:
United States: Institutional Review Board
Study ID:
0803009687
NCT ID:
NCT00749372
Start Date:
September 2008
Completion Date:
June 2011
Related Keywords:
- Myelodysplastic Syndrome (MDS)
- Myelodysplastic Syndromes
- Preleukemia
Name | Location |
|---|---|
| Weill Medical College of Cornell University | New York, New York 10021 |
