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Impact of a Capsular Incision on Biochemical Recurrence After Radical Perineal Prostatectomy

43 Years
78 Years
Not Enrolling
Radical Perineal Prostatectomy

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Trial Information

Impact of a Capsular Incision on Biochemical Recurrence After Radical Perineal Prostatectomy

The pathological classification of the prostate following radical prostatectomy provides
important prognostic information; an accurate pathology report is the cornerstone to cancer
treatment and follow-up. In addition to the preoperative serum PSA, Gleason score on
pathology specimens, seminal vesicle invasion and lymph node status, and a positive surgical
margin with extraprostatic extension (EPE) are significant predictors of clinical and
biochemical recurrence. However, the prognostic implication of a capsular incision, a tumor
extending to the inked margins without a histologically documented EPE, remains to be

Inclusion Criteria:

- pathologically proven prostate cancer

- follow-up for at least 6 months

Exclusion Criteria:

- insufficient biopsy data

- seminal vesicle invasion or lymph node involvement on pathology

- neoadjuvant or adjuvant therapy

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

biochemical recurrence of prostate cancer

Outcome Time Frame:

upto the final date of study

Safety Issue:


Principal Investigator

han yong Choi, professor

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine


Korea: Food and Drug Administration

Study ID:

SMC IRB 2008-08-012



Start Date:

June 1995

Completion Date:

January 2008

Related Keywords:

  • Radical Perineal Prostatectomy
  • capsular incision
  • biochemical recurrence
  • radical perineal prostatectomy
  • Recurrence