Inclusion Criteria:

- 18 years of age

- Deemed a candidate for cryotherapy based on physician physical or medical history
review

- Deemed operable based on institutional criteria

- Able to sign informed consent

- Documented lung or other visceral cancer with pleural involvement.

- WBC > 4,000/mm3, platelets >100,000mm3

- Physically well enough to undergo moderate sedation and pleuroscopy

- Female patients must be HCG negative

- There should be direct evidence of disease progression despite treatment in
previously treated patients

Exclusion Criteria:

- Pregnant or nursing

- Planning to sire a child while enrolled in the study

- Known history of unresolved drug or alcohol dependency that would limit ability to
comprehend or follow instructions related to informed consent, post-treatment
instructions, or follow-up guidelines.

- Refusal or inability to give consent.

- Concurrent chemotherapy.

- Medical contraindication or potential problem that would preclude study participation

- Concurrent participation in other experimental studies

- Uncontrolled coagulopathy or bleeding diathesis

- Serious medical illness, including:

- Uncontrolled congestive heart failure

- Uncontrolled angina

- Myocardial infarction

- Cerebrovascular accident within 6 months prior to study entry