Inclusion Criteria:

- Age ≥ 18 years

- Incurable, locally advanced, or metastatic solid malignancy that has progressed on,
or failed to respond to, at least one prior regimen

- Evaluable or measurable disease per RECIST (in certain circumstances, prostate or
ovarian cancer patients with non-measurable disease)

Exclusion Criteria:

- Inadequate hematologic or organ function

- Anti-cancer therapy within 4 weeks prior to initiation of study treatment

- Recent history of or current clinically significant gastrointestinal, cardiovascular
or pulmonary disorders

- Any condition requiring full-dose anticoagulants, such as warfarin, heparin, or
thrombolytics, or a filter of the inferior vena cava

- Active infection or autoimmune disease

- Known human immunodeficiency virus (HIV) infection

- Pregnancy or breast feeding