Know Cancer

forgot password

A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined With Dasatinib to Docetaxel Combined With Placebo in Castration-Resistant Prostate Cancer

Phase 3
18 Years
Open (Enrolling)
Prostatic Neoplasms

Thank you

Trial Information

A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined With Dasatinib to Docetaxel Combined With Placebo in Castration-Resistant Prostate Cancer

Inclusion Criteria:

- Histologically diagnosed prostate cancer

- Evidence of metastatic disease

- Evidence of progression, by rising PSA, nodal/visceral disease, bone scan, or local

- Serum testosterone ≤ 50 ng/dL

- Must be able to take oral medications

- Performance status 0, 1 or 2

Exclusion Criteria:

- Symptomatic brain or leptomeningeal metastases

- Clinically significant cardiovascular disease

- Pleural or pericardial effusion

- Currently active second malignancy

- Uncontrolled intercurrent illness

- Prior cytotoxic chemotherapy, with the exception of estramustine

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Overall survival

Outcome Time Frame:

Assessed at each study visit (every 3 weeks while on treatment and every 12 weeks during follow-up) to death

Safety Issue:


Principal Investigator

Bristol-Myers Squibb

Investigator Role:

Study Director

Investigator Affiliation:

Bristol-Myers Squibb


United States: Food and Drug Administration

Study ID:




Start Date:

October 2008

Completion Date:

February 2013

Related Keywords:

  • Prostatic Neoplasms
  • Neoplasms
  • Prostatic Neoplasms



Roswell Park Cancer Institute Buffalo, New York  14263
Memorial Sloan-Kettering Cancer Center New York, New York  10021
Midwestern Regional Medical Center Zion, Illinois  60099
University of Tennessee Cancer Institute Memphis, Tennessee  38103
Summa Health System Akron, Ohio  44312
Cancer Centers of the Carolinas Greenville, South Carolina  29605
Highlands Oncology Group, P.A. Fayetteville, Arkansas  72703
Jackson Oncology Associates, PLLC Jackson, Mississippi  39202
University of Washington Seattle, Washington  98195
Duke University Medical Center Durham, North Carolina  27710
University of Chicago Chicago, Illinois  60637
Tufts Medical Center Boston, Massachusetts  02111
Compassionate Cancer Care medical Group, Inc. Fountain Valley, California  92708
VA Connecticut Healthcare System West Haven, Connecticut  06516
Cancer Specialists of South Texas, PA Corpus Christi, Texas  78412
Sharp Clinical Oncology Research San Diego, California  92123
Connecticut Oncology Group Middletown, Connecticut  06457
Alaska Clinical Research Center Anchorage, Alaska  99508
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
VA San Diego Healthcare System San Diego, California  92161
Cancer Center of Kansas Wichita, Kansas  67214
New York Oncology Hematology, PC Albany, New York  12208
Maine Center for Cancer Medicine Scarborough, Maine  04074
The University of Texas MD Anderson Cancer Center Houston, Texas  77030-4009
Desert Hematology Oncology Medical Group Rancho Mirage, California  92270
Suburban Hematology-Oncology Associates, Pc Lawrenceville, Georgia  30046
UPMC Cancer Pavilion Pittsburgh, Pennsylvania  15232
Southern Cancer Center Mobile, Alabama  36608
The Miriam Hospital Providence, Rhode Island  02903
Providence Portland Med Ctr Portland, Oregon  97213
Piedmont Hematology Oncology Associates, PA Winston Salem, North Carolina  27103
University Of South Alabama / Mitchell Cancer Institute Mobile, Alabama  36604
Edward Alexson, Md, Inc. Santa Ana, California  92705
Fort Wayne Medical Oncology And Hematology Inc Fort Wayne, Indiana  46845
North Mississippi Hematology And Oncology Associates, Ltd Tupelo, Mississippi  38801
Samuel S. Stratton Dept. Of Vet. Affairs Med. Ctr. Albany, New York  12208
Mid Ohio Oncology/Hematology, Inc,Dba Columbus, Ohio  43219
Regional Hematology Oncology Associates Pc Langhorne, Pennsylvania  19047
Va Medical Center Pittsburgh Healthcare System Pittsburgh, Pennsylvania  15240
Associates In Hematology & Oncology, P.C. Upland, Pennsylvania  19013
Providence Regional Cancer System Lacey, Washington  98503