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Prospective Comparative Study of Immunological Benefit Between Laparoscopic Colectomy and Open Colectomy


N/A
20 Years
80 Years
Not Enrolling
Both
Immunity

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Trial Information

Prospective Comparative Study of Immunological Benefit Between Laparoscopic Colectomy and Open Colectomy


Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively
assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host
(total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on
monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the
5th day of operation (POD5).


Inclusion Criteria:



- Biopsy proven of colon cancer

- Preoperatively suspected as clinical stage III colon cancer

- Lesion located Descending colon, sigmoid colon and upper rectal cancer

Exclusion Criteria:

- Could not perform curative resection

- Intestinal obstruction, perforation, intra-abdominal abscess

- Severe medical illness

- Immunopathy

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Immune factors

Outcome Time Frame:

post OP 5th day

Safety Issue:

No

Principal Investigator

Woo Yong Lee, MD,PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Samsung Medical Center

Authority:

South Korea: Institutional Review Board

Study ID:

IRB 2005-08-041

NCT ID:

NCT00744159

Start Date:

January 2006

Completion Date:

November 2007

Related Keywords:

  • Immunity
  • colon cancer
  • laparoscopic colorectal surgery
  • cellular immunity
  • HLA-DR expression on monocyte

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