Trial Information

Examination of Healthy Female Subjects in the Project: Disposing Factors for Chronic Pain After Operation for Breast Cancer

Surgery for breast cancer is followed by acute undesirable sequelae (pain, nausea, vomiting,
psycho-social adaptation) and late sequelae with discomfort or more severe neuropathic pain
problems in the surgical area due to nerve damage or adjuvant-/radiotherapy. The late
sequelae occur in 30-50% of patients but the exact mechanisms (preoperative disposing
factors, intraoperative nerve damage/inflammatory response), acute postoperative pain and
psychosocial factors remain to be determined in large, detailed, well-described studies,
including stratification to modern breast cancer treatment (sentinel node strategy/
radiotherapy/ chemotherapy). The present study will describe in detail preoperative
psychosocial/genetic pain mechanisms, intraoperative technique, multi-modal anaesthesia and
opioid-reduced analgesia with a detailed, early and late postoperative follow-up with
neurophysiological assessment in the surgical area and randomised studies on preventive
therapy.