Inclusion Criteria:

1. Patients with histologic confirmation of metastatic (stage IV) 'triple
receptor-negative' breast cancer. Tissue must be available at baseline or agree to
biopsy. The diagnosis of 'triple receptor-negative' breast cancer requires that
either the primary tumor or a metastatic deposit be shown to be negative for estrogen
receptors (ER) and progesterone receptors (PR) by immunohistochemistry (IHC) and for
HER2/neu by IHC (i.e. a score of 0 and 1+) or fluorescent in situ hybridization
(FISH).

2. EGFR protein expression and gene copy number will be evaluated on stored tissue
sample at a later time. Unstained slides, a block, or agreement for biopsy is
required for study participation.

3. Patients with metastatic breast cancer to any distant site are eligible once their
disease is clinically/radiologically measurable

4. Patients must have disease which is resistant to taxanes and anthracyclines. There is
no limit to the number of previous therapies for metastatic disease.

5. Patients are eligible if they have not had prior exposure to an EGFR inhibitor
(e.g.Gefitinib, Erlotinib) or antibody (e.g. Cetuximab).

6. Availability of tissue blocks and/or fresh/frozen tumor samples is an eligibility
requirement in order to run the EGFR IHC, FISH and to confirm, if needed ER, PR and
HER2/neu status.

7. Patients may, but are not required, to have a repeat tumor biopsy performed on study
entry prior to beginning therapy and also early during study therapy for correlative
studies.

8. Patients with 'triple receptor-negative' metaplastic breast cancers are eligible if
they meet the criterion of EGFR overexpression.

9. Patients must sign an informed consent indicating that they are aware of the
investigational nature of the study, in keeping with institutional policy

10. Patients must have tissue blocks available from previous primary tumor surgery or
biopsy or from a previous biopsy of metastatic disease for EGFR status assessment and
for correlative studies

11. Patients should have adequate bone marrow function, as defined by peripheral
granulocyte count of >/= 1500/mm^3, and a platelet count >/= 100000/ mm^3. Patients
must have adequate liver function with a bilirubin within 1.5 times the upper limit
of normal (ULN). Transaminases (SGPT) may be up to 5 * the ULN and alkaline
phosphatase may be up to 5 * ULN

12. Patients should have adequate renal function (serum creatinine
13. Negative pregnancy test for a woman of childbearing potential

14. Women of childbearing potential must use a reliable and appropriate contraceptive
method during the study

15. Patients with a performance status of 2 or better by World Health Organization
(W.H.O.)

Exclusion Criteria:

1. Patients with uncompensated congestive cardiac failure are not eligible

2. Patients with a myocardial infarction in the previous 12 months are not eligible

3. Patients with central nervous system (CNS) metastases are not eligible

4. Patients with an organ allograft

5. Patients with a serious concurrent infection or illness including, but not limited
to, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that would
limit compliance with study requirements