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Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination


N/A
N/A
N/A
Not Enrolling
Female
Infertility, Clinical Pregnancy Rate

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Trial Information

Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination


Endometrial sampling is performed using the standard technique in the outpatient department.
Similarly, superovulation with gonadotrophins will be performed according to our standard
practice.Endometrial sampling will be done in the follicular phase not later than day 10 of
the cycle. Endometrial sampling will be performed using Pipelle sampling catheter. The
Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced
slowly till just resistance felt by the operator. Then, the piston is withdrawn to create
negative suction and gentle movement of Pipelle up and down in the uterine cavity is
performed while it is against the uterine wall. The Pipelle catheter is withdrawn gently and
any obtained specimen will be sent for histopathological examination.


Inclusion Criteria:



1. All women undergoing superovulation with gonadotrophins and intrauterine
insemination.

2. All women with cervical factor, mild male factor and/or unexplained infertility.

3. At least one patent Fallopian tube.

Exclusion Criteria:

1. Bilateral tubal disease

2. Severe male factor infertility

3. Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions)

4. Women with positive cervical culture and/or acute vaginal infection

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

The rate of clinical pregnancy

Outcome Time Frame:

24 months

Safety Issue:

Yes

Principal Investigator

Togas Tulandi, MD, MHCM

Investigator Role:

Principal Investigator

Investigator Affiliation:

McGill University Health Center

Authority:

Canada: Ethics Review Committee

Study ID:

SDR-08-004

NCT ID:

NCT00737984

Start Date:

August 2008

Completion Date:

August 2011

Related Keywords:

  • Infertility
  • Clinical Pregnancy Rate
  • Infertility
  • Clinical pregnancy rate
  • Infertility
  • Adenoma

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