Inclusion Criteria:

- Age > 18 years

- Histologically and/or cytologically confirmed adenocarcinoma of the pancreas, T1-4,
N0-1, M0. Patients should have disease for which combined modality therapy is
indicated.

- Performance status 0-2

- Life expectancy > 3 months

- Adequate hematologic, renal, hepatic function

- Calculated creatinine Cl > 50 mL/min

- Use of effective means of contraception in patients of child-bearing potential.

Exclusion Criteria:

- No prior therapy for pancreatic cancer

- Previous treatment with bevacizumab or erlotinib

- Evidence of duodenal invasion or gastric outlet obstruction

- Presence of bleeding diathesis or coagulopathy

- History or prior arterial thrombotic event

- Conditions leading to inadequate gastrointestinal tract absorption

- Poorly controlled diarrhea .

- Presence of baseline proteinuria or renal dysfunction (CrCl < 50 (Cockcroft-Gault
equation)

- Inadequately controlled hypertension

- New York Heart Association (NYHA) Grade II or greater congestive heart failure

- Clinically significant peripheral vascular disease

- Presence of central nervous system or brain metastases

- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to Day 0, anticipation of need for major surgical procedure during the course
of the study

- Minor surgical procedures such as fine needle aspirations or core biopsies within 7
days prior to Day 0

- Pregnant or lactating females

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 6 months prior to Day 0

- Serious, non-healing wound, ulcer, or bone fracture

- Inability to comply with study and/or follow-up procedures

- Treatment for other carcinomas within the last five years, except cured non-melanoma
skin cancer, curatively treated in-situ cervical cancer, or localized prostate cancer
with a current PSA of <1.0 mg/dL on 2 successive evaluations, at least 3 months
apart, with the most recent evaluation no more than 4 weeks prior to entry.

- Comorbid conditions that would complicate safety or compliance