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Optical Coherence Tomography of Human Airways


Phase 1
N/A
N/A
Not Enrolling
Both
Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Nonmalignant Neoplasm, Precancerous Condition

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Trial Information

Optical Coherence Tomography of Human Airways


OBJECTIVES:

- Correlate optical coherence tomography images of the airway with airway histology.

- Develop an imaging technique to detect premalignant airway epithelial changes
(carcinoma in situ, dysplasia) to study the transformation process as well as intervene
and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue
samples collected during surgery. All imaged areas are marked. The marked areas are then
excised and fixed in formalin for histopathologic analysis.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Undergoing pneumonectomy or lobectomy for malignant or benign lung processes

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Outcome Measure:

Correlation of optical coherence tomography images of the airway with airway histology

Outcome Time Frame:

This study will involve discarded tissue from 10 subjects with pathology specimens over one year.

Safety Issue:

No

Principal Investigator

Rana Hejal, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

CASE1508

NCT ID:

NCT00733252

Start Date:

April 2008

Completion Date:

February 2011

Related Keywords:

  • Lung Cancer
  • Malignant Mesothelioma
  • Metastatic Cancer
  • Nonmalignant Neoplasm
  • Precancerous Condition
  • non-small cell lung cancer
  • small cell lung cancer
  • benign respiratory tract neoplasm
  • lung papilloma
  • recurrent respiratory papillomatosis
  • squamous lung dysplasia
  • malignant mesothelioma
  • pulmonary carcinoid tumor
  • lung metastases
  • Neoplasms
  • Lung Neoplasms
  • Mesothelioma
  • Neoplasm Metastasis
  • Neoplasms, Second Primary
  • Precancerous Conditions

Name

Location
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065