Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?
26 Years
72 Years
Both
Cholangiocarcinoma, Surgical Treatment, Hepatectomy
Trial Information
Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?
Objective: To determine the safety and efficacy of minor and major hepatectomy selected by
predetermined criteria in patients with hilar cholangiocarcinoma (HC).
Summary Background Data: For HC treated with hepatectomy, the extent of liver resection
remains controversial despite extensive studies.
Methods: From January 2000 to December 2007, we prospectively studied patients who received
surgical treatment for HC. Of the 187 patients who were surgically treated, 138 (73.8%)
underwent resection with a curative intent. Minor hepatectomy was carried out in 93 patients
who had Bismuth-Corlette types I, II and III HC without hepatic artery/portal vein invasion;
and major hepatectomy in 45 patients who had type III HC with hepatic artery/portal vein
invasion, or type IV HC.
Inclusion Criteria:
- Criteria for resectability were absence of peritoneal or liver metastases, tumor
extension to beyond secondary biliary branches bilaterally, tumor extension to
secondary portal venous branches bilaterally
Exclusion Criteria:
- not in accordance with the above criteria
Type of Study:
Interventional
Study Design:
N/A
Outcome Measure:
On multivariate analysis, prognostic factors significantly impacted on long-term survival were UICC tumor stage and histopathologic grade.
Authority:
China: Food and Drug Administration
Study ID:
chenxp002
NCT ID:
NCT00733200
Start Date:
Completion Date:
Related Keywords:
- Cholangiocarcinoma
- Surgical Treatment
- Hepatectomy
- Minor Liver Resection
- Major Liver Resection
- Hilar
- Cholangiocarcinoma
- Klatskin's Tumor
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