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Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

26 Years
72 Years
Not Enrolling
Cholangiocarcinoma, Surgical Treatment, Hepatectomy

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Trial Information

Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

Objective: To determine the safety and efficacy of minor and major hepatectomy selected by
predetermined criteria in patients with hilar cholangiocarcinoma (HC).

Summary Background Data: For HC treated with hepatectomy, the extent of liver resection
remains controversial despite extensive studies.

Methods: From January 2000 to December 2007, we prospectively studied patients who received
surgical treatment for HC. Of the 187 patients who were surgically treated, 138 (73.8%)
underwent resection with a curative intent. Minor hepatectomy was carried out in 93 patients
who had Bismuth-Corlette types I, II and III HC without hepatic artery/portal vein invasion;
and major hepatectomy in 45 patients who had type III HC with hepatic artery/portal vein
invasion, or type IV HC.

Inclusion Criteria:

- Criteria for resectability were absence of peritoneal or liver metastases, tumor
extension to beyond secondary biliary branches bilaterally, tumor extension to
secondary portal venous branches bilaterally

Exclusion Criteria:

- not in accordance with the above criteria

Type of Study:


Study Design:


Outcome Measure:

On multivariate analysis, prognostic factors significantly impacted on long-term survival were UICC tumor stage and histopathologic grade.


China: Food and Drug Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Cholangiocarcinoma
  • Surgical Treatment
  • Hepatectomy
  • Minor Liver Resection
  • Major Liver Resection
  • Hilar
  • Cholangiocarcinoma
  • Klatskin's Tumor