In-Vitro Studies in Depletion of Haplotype Mismatched Alloreactive T Cells
The purpose of this research is to study how immune cells (called T cells) that cause
graft-versus-host disease (GVHD) can best be selectively separated from other T cells and
removed from the cells that will be returned to the cancer patient's body. These other T
cells may protect against infection when given to patients after a stem cell transplant.
The removal of cells that cause GVHD would allow doctors to safely give back the T cells
that protect against infection, without the risk of GVHD.
Observational Model: Case-Only, Time Perspective: Prospective
To develop the optimum conditions for activating the maximum number of alloreactive T cells from clinical scale samples
Sherif Farag, MD, PhD
Indiana University Melvin and Bren Simon Cancer Center
United States: Institutional Review Board