Inclusion Criteria:

- Age 18-26 years.

- Patients hospitalized during the postpartum period after a normal spontaneous vaginal
delivery, assisted vaginal delivery or Cesarean section.

- Patients who delivered a singleton fetus or multiple gestations are eligible for
participation.

- Patients may have delivered at gestational ages 32-44 weeks.

- Patients must have signed informed consent.

- Patients must meet pre-entry criteria.

- Patients who are breast feeding are eligible for participation.

- Patients must have an obstetrician whom they have seen for obstetric care and plan to
follow-up with in the postpartum period.

Exclusion Criteria:

- Age < 18 or > 26 years.

- Patients with hemophilia, other bleeding disorders or thrombocytopenia (platelets <
100,000/ul).

- Patients receiving active anticoagulant therapy with warfarin, heparin or low
molecular weight heparin.

- Pregnancy or planning pregnancy within the next 6 months.

- Ongoing bacteremia, endomyometritis or other serious febrile illness.

- Hypersensitivity to yeast, aluminum or other vaccine components.

- Prior vaccination with a prophylactic HPV vaccine (single or multiple doses).

- Patients who delivered a non-viable infant or an infant with severe congenital
malformations.

- Patients who do not plan on following up postpartum with their local obstetrician or
maternal fetal medicine specialist.

- Patients who are unwilling to receive subsequent doses of the HPV vaccine.