Determination if Pharmacologic Blockade of Androgen Action Decreases Renal Clearance of DCI, Increases the Circulating Concentration of DCI, and Enhances Insulin-Stimulated Release of the DCI-IPG Mediator in Obese Women With PCOS
Hyperinsulinemia stimulates ovarian production of androgens, especially testosterone, in
PCOS. Therefore, it is theoretically possible that testosterone increases uClDCI in PCOS,
and that this serves as the explanation for the correlation between uClDCI and insulin
sensitivity. While we regard this possibility as unlikely, it is important that it be
tested. To accomplish this, we will assess obese (BMI >30 kg/m2) women with and without
PCOS at baseline, and again after 4 weeks of androgen action blockade with the drug
flutamide. Flutamide is an antiandrogen that works by blocking the binding of androgens to
the androgen receptor.
We will determine if this pharmacologic blockade i) decreases the renal clearance of DCI,
ii) increases the circulating concentration of DCi, and iii) enhances the insulin-stimulated
release of the DCI-IPG mediator during an OGTT.
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Health Services Research
DCI-IPG measurements in blood and urine
John E. Nestler, M.D.
Virginia Commonwealth University
United States: Federal Government
|Virginia Commonwealth University General Clinical Research Center||Richmond, Virginia 23298|