Inclusion Criteria:

- Diagnosed with early, resectable breast cancer (Stage I or II)

- Completed treatment with surgery, radiation, and/or chemotherapy between 6 months and
5 years previously

- No other cancer in last 5 years, including breast cancer recurrence

- Postmenopausal women

- Age 40 - 65

- Reporting persistent cancer-related fatigue

Exclusion Criteria:

- Evidence that fatigue is directly related to a medical or psychiatric disorder (e.g.,
untreated hypothyroidism, diabetes, anemia (defined as hematocrit < 24), chronic
fatigue syndrome, current major depression, insomnia, sleep apnea, restless leg
syndrome)

- Evidence that fatigue is related to other non-cancer related factors (e.g., shift
work, recent change in activity or schedule)

- Physical problems or conditions that could make yoga unsafe (e.g., serious neck
injuries, unstable joints; also severe cachexia, dizziness, bone pain, severe nausea,
etc)

- Regular use of medications and/or behavioral therapies that would confound
evaluation of IY, including regular participation in yoga classes

- Presence of medical conditions that involve the immune system and would confound
immune evaluation (e.g., autoimmune disorder, inflammatory disease)

- Use of medications that might confound immune evaluation (e.g., regular use of
corticosteroids, narcotics, opiates)

- Unable to commit to intervention schedule

- Body mass index greater than 30 kg/m2

- Regular tobacco (defined as daily or near daily) or alcohol use (defined as > 2
drinks/day)