Inclusion Criteria:

1. Crohn's disease, ulcerative colitis, or indeterminate colitis diagnosed by standard
clinical, radiographic, endoscopic, and histologic criteria.

2. Actively followed by a physician at the Children's' Hospital gastroenterology (GI) or
IBD Center, or patient is referred by local clinic or hospital for our study.

3. Female gender

4. Age 9-26 years

5. Patient (18 years old) or parent is willing to provide informed consent.

6. Is currently on an immunomodulator and/or TNF inhibitor for ≥ 30 days prior to
enrollment. Patients may also be using prednisone or aminosalicylates in addition to
the immunomodulator or TNF inhibitor. Standard concomitant medications (e.g.
antibiotics, antihistamines, acetaminophen) will be allowed

Exclusion Criteria:

1. Male gender

2. Unwilling to provide consent

3. New immunomodulator added within the last 30 days, and was not previously on any
immunomodulator

4. History of bleeding disorder that would make hematoma likely (e.g., hemophilia, von
Willebrand's disease) or on anti-coagulation therapy (certain cases may be allowed;
each case will be assessed by study doctor)

5. Hypersensitivity to the ingredients/components of the vaccine (e.g., aluminum, yeast)

6. Known pregnancy or positive pregnancy test. We will obtain a urinary pregnancy test
before each dose of the vaccine is administered. Subjects participating will be
informed during the consent/assent procedures that the safety of this vaccine has not
been proven in pregnant women, and will be advised not to become pregnant during the
study and counseled according to the guidelines of the Children's Hospital IRB.

7. Previously received HPV vaccination.