Inclusion Criteria:

- Post mortal kidney donation or living donation

- Primary and secondary renal transplantation, unless the graft was lost due to severe
rejection within the first year

- PRA level ≤ 20%.

- Recipient ≥ 18 to 75 years of age

- AB0-compatible

- Negative crosshatch

- Patients with a signed informed consent form

- Women of child-bearing age must agree to an efficient contraception

Exclusion Criteria:

- Third or multiple transplantation

- Transplantation per a "non-heart beating" donor

- HLA-identical living donation

- Incompatibility to study medication (allergy, intolerance, hypersensitivity)

- Patients with existing malignant underlying disease or tumour anamnesis < 5 years.
Exception: basaloma or squamous cell carcinoma of the skin after successful therapy

- Female patients who do not use a safe method of contraception

- Patients with clinically significant, uncontrolled infectious diseases (incl. HIV)
and/or severe diarrhoea, emesis, active malabsorption of the upper gastrointestinal
tract or active peptic ulcer

- Patients currently, resp. within the last 30 days, participating in other studies

- Primary focal-sclerosing glomerulonephritis and membranoproliferative
glomerulonephritis as an underlying disease

- Autoimmune disease as underlying disease (collagen diseases, colitis, HUS, SLE) which
might require chronic cortisone therapy

- Additional disease requiring temporary or chronic cortisone therapy (including
inhalation medicine)

- Chronic hepatitis B and hepatitis C infection

- Thrombopenia < 70.000/mm3 or leukopenia < 2.500/mm3 or neutropenia < 1500/ mm3.

- Patients with hepatocirrhosis Child B or C or another severe disease of the liver

- Patients with symptoms of a significant somatic or psychiatric / mental illness.
Patients who are not able to realize nature, relevance and consequences of the
clinical trial and who are not able to comply, to cooperate and communicate
adequately and to follow the instructions of the study or even to give their informed
consent (according to § 40 article 4 and § 41 article 2 and 3 AMG).

- Patients who possibly depend on the sponsor or the trial physician

- Patients with signs of drug abuse or alcohol abuse

- Patients taking additional medicines with known interactions with the immune
suppressive substances (MMF and tacrolimus) that preclude an adequate control of the
immunosuppression

- Cold ischemia time of donor kidney > 30 hours

- Pregnant or nursing patients