Inclusion Criteria

Inclusion

- Patients with CD20-expressing B cell NHL that is relapsed or refractory to standard
therapy; CLL/SLL with peripheral blood leukemia/lymphoma cells and high-grade
lymphomas (i.e., lymphoblastic lymphoma/Burkitt lymphoma) are excluded

- Patients must have received prior Rituxan

- Measurable disease; in the absence of lymphadenopathy, splenomegaly with defects or
measurable extramedullary disease is acceptable; however, bone marrow involvement
alone will not be included in the study

- Age >=18 years and <=65 physiologic years of age

- KPS >= 70%

- Life expectancy >= 12 weeks

- Serum creatinine =< 1.5 mg/dl

- Total WBC >= 3000/ul or absolute neutrophil count (ANC) >= 1000/ul

- Lymphocyte count >= 0.2 x 10^3/ul

- Platelet count >= 75,000/ul

- Hematocrit >= 25% or hemoglobin >= 9 g/100 ml

- Alanine aminotransferase (ALT) =< 2.5 x UNL

- Aspartate aminotransferase (AST) =< 2.5 x UNL

- Total bilirubin (TBili) < 1.5 x UNL

- Sodium, potassium, and phosphorus within normal limits

- Chest x ray (CXR) within 4 weeks prior to Day 1 with no evidence of pulmonary
congestion, pleural effusions, pulmonary fibrosis, or significant emphysema; if
results are questionable, subjects would have additional lung function testing to
exclude clinically relevant restriction or obstruction; subjects must have an FEV-1
and DLCO of at least 65% and 50% of expected, respectively

- Electrocardiogram (12-lead ECG)

- Echocardiogram (or MUGA) with normal left ventricular function

- Cardiac stress test (e.g., stress thallium scan, stress echocardiography) with normal
results if subject is suspected to have coronary artery disease

- Fasting blood glucose (FBG) < 160 and hemoglobin (Hgb) A1C < 7% for subjects with
diabetes mellitus (DM) or borderline DM

- Women of procreative potential must have negative pregnancy test within the 2-week
screening phase prior to Cycle 1, and all subjects of procreative potential must use
adequate birth control throughout the study; subjects of procreative potential are
defined as any fertile male, and any female who has experienced menarche and has not
undergone successful surgical sterilization (hysterectomy or bilateral oophorectomy)
or is not post-menopausal, defined as age-related amenorrhea >= 12 months

- Provide written informed consent prior to any screening procedures

Exclusion

- Evidence of CNS lymphoma or lymphomatous meningitis

- Prior treatment with IL-2

- Type I hypersensitivity or anaphylactic reactions to murine proteins or to previous
infusion of rituximab

- Pregnant or lactating female

- An immediate need for palliative radiotherapy or systemic corticosteroid therapy

- Known intercurrent infections (including hepatitis C virus [HCV] and HIV or other
conditions), or clinical evidence of these conditions

- Actively infected with or chronic carriers of hepatitis B virus (HBV) as demonstrated
by positive hepatitis B core antibody (HbcHb) or hepatitis B surface antigen (HbsAg);
(subjects who are sero-positive only, i.e., surface antibody positive [HbsAg], are
permitted)

- Other significant active infection

- Major surgery, chemotherapy, investigational agent, or radiation within 30 days of
Day 1

- Uncontrolled hypertension (diastolic >= 100 mmHg) or hypotension (systolic =< 90
mmHg)

- History of repeated and clinically relevant episodes of syncope or other paroxysmal,
ventricular, or other significant arrhythmias

- On ECG: a marked baseline prolongation of QT/QTc interval (> grade 2 QTc interval >
470 milliseconds)

- History of medically significant ascites requiring repetitive paracentesis

- Previous diagnosis of Addison's disease

- Previous diagnosis of autoimmune disease (exceptions: subjects with autoimmune
thyroiditis or vitiligo may be enrolled)

- Organ transplant recipient

- History of prior therapy or a serious, uncontrolled medical disorder that in the
investigator's opinion would impair participation in the study

- Known hypersensitivity to Tween-80 or human immunoglobulin

- Legal incapacity or limited legal capacity

- Patients with bulky lymph nodes (>= 10cm) or marked splenomegaly (i.e., extending
into pelvis or crossing the midline)

- Positive anti-DI-Leu16-IL2 antibody assay (where positive is defined as > 10% of the
radiolabeled DI-Leu16-IL2 reactive with the subject's serum)