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The Relationship Between Vitamin D and Thyroid Cancer

19 Years
Not Enrolling
Thyroid Cancer

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Trial Information

The Relationship Between Vitamin D and Thyroid Cancer

Thyroid cancer is the most common endocrine related malignancy, increasing in incidence in
recent years. There are relatively few, well known factors, both genetic and environmental,
which predispose to the development of thyroid cancer. Vitamin D deficiency has been
associated with other cancers, but the association between vitamin D and thyroid cancer is
unknown. We plan to do a case control, pilot study to evaluate the relationship between
vitamin D levels and thyroid nodules, thyroid cancer in remission, and active thyroid

Inclusion Criteria:

- Cases: History of Papillary, Follicular, Follicular Variant of Papillary, or Hurthle
cell thyroid cancer (both active disease and in remission).

- Controls: Individuals with a thyroid nodule, matched to cases for age, BMI, season of
vitamin D measurement.

- Participating in University of Nebraska Medical Center Thyroid Tumor and Cancer
Collaborative Registry database.

Exclusion Criteria:

- Pregnant or breast feeding women

- Medullary thyroid cancer

- Anaplastic thyroid cancer

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Number of Persons That Are Vitamin D Deficient in the Thyroid Nodule, Thyroid Cancer in Remission, and the Active Thyroid Cancer Groups.

Outcome Description:

We evaluated serum calcium,creatinine,albumin,and 25-hydroxyvitaminD(25-OH-D)in 42 thyroid nodule, 45 thyroid cancer in remission, & 24 active thyroid cancer patients. We also determined the number and percent of participants in each group that had vitamin D deficiency, defined as 25-OH-D < 30 ng/ml.

Outcome Time Frame:

Within 12 months of enrollment in thyroid cancer collaborative registry (TCCR) database

Safety Issue:


Principal Investigator

Nathan W Laney, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Nebraska Medical Center, Department of Internal Medicine, Section of DEM


United States: Institutional Review Board

Study ID:




Start Date:

March 2008

Completion Date:

June 2009

Related Keywords:

  • Thyroid Cancer
  • Thyroid Cancer
  • Thyroid Nodules
  • Vitamin D
  • Thyroid Neoplasms
  • Thyroid Diseases



University of Nebraska Medical CenterOmaha, Nebraska  68198-3330