Polycythemia Vera, Myelofibrosis and Essential Thrombocythemia: Identification of PV, MF & ET Genes
Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF), also
known as the Philadelphia Chromosome negative myeloproliferative disorders (MPDs), are not
congenital, but acquired. The purpose of this project is to find genes whose mutations cause
these disorders, as well as improve diagnostic measures for these diseases. When this is
accomplished new therapies to control and eventually cure the disease can be designed.
All subjects will be asked to donate 4-6 teaspoons of blood. On occasion, if the blood
cells from a particular sample do not grow well and the DNA from that sample is used up or
other tests are needed, we may ask to collect additional samples. In patients who have
undergone a bone marrow biopsy as part of their clinical evaluation, we will test the
reproducibility between pathologists for the revised 2008 WHO diagnostic criteria to
diagnose myeloproliferative disorders (MPD).
Observational Model: Case Control, Time Perspective: Prospective
Identify genes whose mutations cause Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis.
Josef T Prchal, MD
University of Utah
United States: Institutional Review Board
|University of Utah||Salt Lake City, Utah|