Hypoxia-PET and IMPT Dose Painting in Patients With Chordomas: A Pilot Study
- In this research study we are determining whether the positron emission tomography
(PET) investigation performed with the investigational radioactive substance FMISO can
show areas of tumor with lower oxygen levels. There is evidence that tumor with low
oxygen levels are more resistant to radiation therapy. CT and MRI scans are not able to
detect these oxygen levels in tumors.
- Participants will be asked to have the FMISO-PET/CT scan at 2 different times. It will
be performed 2 weeks before and 3 weeks after the participants first proton radiation
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
To evaluate if FMISO-PET is a feasible approach for the visualization of hypoxia in skull base and spinal CD.
Thomas F. DeLaney, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|