A Phase I Study Evaluating the Safety, Pharmacokinetics, Tissue Distribution, Metabolism of Small Molecule Inhibitors of Prostate Specific Membrane Antigen: Determination of I-123 Radiation Dosimetry for 123-I-MIP-1072 and 123-I-MIP-1095
Inclusion Criteria:
- Have a prior histological diagnosis of prostate cancer.
- Have evidence of recurrent metastatic disease demonstrated by an abnormal bone scan,
CT scan or MRI plus:
1. PSA> 1.0 if patient is post prostatectomy or post ablative radiotherapy, or
2. PSA> 20 if intact prostate
- Have platelet count of > 50,000/mm3
- Have neutrophil count of > 1,000/mm3
- Provide written informed consent and willing to comply with protocol requirements
- Greater than or equal to 18 years of age
- Can be on hormonal therapy if dose stable for > 90 days
Exclusion Criteria:
- Karnofsky performance status of <60
- Inadequate venous access (two antecubital or equivalent venous access sites are
required for study drug injection and PK blood sampling, respectively)
- Patient received a permanent prostate brachytherapy implant within the last 3 months
(for Pd-103 implants) or 12 months (for I-125 implants).
- Patient received external beam therapy or chemotherapy within the last 30 days
- Administered a radioisotope within 5 physical half lives prior to study enrollment
- Serum creatinine > 3.5 mg/dL
- Total bilirubin > 2.5 times the upper limit of normal
- Liver transaminases greater than 5x the upper limit of normal
- Received an investigational compound and/or medical device or is part of an
investigational study within the past 30 days before enrollment into this study
- Have any medical condition or other circumstances which, in the opinion of the
Investigator, would significantly decrease the chances of obtaining reliable data,
achieving study objectives, or completing the study and/or post dose follow-up
examinations
- Is determined by the Investigator that the patient is clinically unsuitable for the
study
- Have had any other malignancies within 5 years other than basal or squamous cell
carcinoma of the skin.