Inclusion Criteria:
- Primary diagnosis of invasive epithelial ovarian cancer FIGO stage IIB-IV (IV only if
resectable metastasis in pleura, liver, spleen, and/or abdominal wall)
- Macroscopic complete resection
- Age: 18 - 75 years
- Patients who have given their signed and written informed consent
- Good performance status (ECOG 0/1)
Exclusion Criteria:
- Non epithelial ovarian malignancies and borderline tumors
- Intraoperative clinically suspicious lymph nodes (bulky nodes)
- Secondary invasive neoplasms in the last 5 years (except synchronal endometrial
carcinoma FIGO IA G1/2, non melanoma skin cancer, breast cancer T1 N0 M0 G1/2) or
with any signs of relapse or activity.
- Recurrent ovarian cancer
- Prior chemotherapy for ovarian cancer or abdominal/pelvic radiotherapy
- Diseases of the lymph system (including lymph edema of unknown origin)
- Clinical relevant dysfunctions of blood clotting (including medicamentous conditioned
reasons, e.g. ASS, if not stopped at least 7 days prior to surgery)
- Any significant medical reasons, age or performance status that will not allow to
perform the study procedures (estimation of investigator)
- Prior retroperitoneal lymph node dissection (systematic or sampling)
- Pregnancy
- Dementia or significantly altered mental status that would prohibit the understanding
and giving of informed consent
- Any reasons interfering with regular follow-up