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Neurotoxicity in Primary Central Nervous System Lymphoma: An International, Collaborative, Observational Study of Cognition in Long-Term Survivors


N/A
18 Years
75 Years
Not Enrolling
Both
Primary Central Nervous System Lymphoma (PCNSL)

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Trial Information

Neurotoxicity in Primary Central Nervous System Lymphoma: An International, Collaborative, Observational Study of Cognition in Long-Term Survivors


This is an international, multi-center project that will enroll as many as 118 subjects of
which approximately 35 will be enrolled at OHSU. Neuropsychological testing will consist of
a battery of paper and pencil tests that examine abilities such as memory, motor skills,
attention and speed of information processing. Questionnaires that assess quality of life
will also be administered. These noninvasive tests are administered by a trained examiner
or neuropsychologist and last about 30 minutes. Subjects will also undergo an MRI of the
head which provides a picture of the brain's structure by placing an individual inside a
powerful magnet. Statistical analyses will examine the relationship between the
neuropsychological test scores and MR images as well as examine the contribution of factors
such as radiation, age, surgery, chemotherapy etc. to cognition.


Inclusion Criteria:



- Radiological and histological diagnosis of PCNSL

- Age 18 years or older

- Survived 2 years or more following treatment

- Able to complete neuropsychological and neuroimaging parts of the study

- Signed a written informed consent in accordance with institutional guidelines

Exclusion Criteria:

- Subject has experienced recurrent disease

- Subject has a contraindication for MRI

- Subject has a contraindication for neuropsychological testing

- Subject has stage IV or V renal insufficiency

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Neuropsychological Functioning

Outcome Time Frame:

More than 2 years after treatment

Safety Issue:

No

Principal Investigator

Edward A Neuwelt, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Oregon Health and Science University

Authority:

United States: Institutional Review Board

Study ID:

OHSU-4093

NCT ID:

NCT00710151

Start Date:

July 2008

Completion Date:

December 2013

Related Keywords:

  • Primary Central Nervous System Lymphoma (PCNSL)
  • neurotoxicity
  • cognition in survivors
  • diagnostic imaging
  • Lymphoma
  • Neurotoxicity Syndromes

Name

Location

Oregon Health & Science UniversityPortland, Oregon  97201