Trial Information

Neurotoxicity in Primary Central Nervous System Lymphoma: An International, Collaborative, Observational Study of Cognition in Long-Term Survivors

This is an international, multi-center project that will enroll as many as 118 subjects of
which approximately 35 will be enrolled at OHSU. Neuropsychological testing will consist of
a battery of paper and pencil tests that examine abilities such as memory, motor skills,
attention and speed of information processing. Questionnaires that assess quality of life
will also be administered. These noninvasive tests are administered by a trained examiner
or neuropsychologist and last about 30 minutes. Subjects will also undergo an MRI of the
head which provides a picture of the brain's structure by placing an individual inside a
powerful magnet. Statistical analyses will examine the relationship between the
neuropsychological test scores and MR images as well as examine the contribution of factors
such as radiation, age, surgery, chemotherapy etc. to cognition.