Inclusion Criteria:

- Histologically or cytologically documented malignancy (solid tumor or lymphoma)

- Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 2

- Predicted life expectancy of at least 3 months

- Adequate hematopoietic and hepatic function, and normal renal function

- Fasting glucose <7mmol/L at baseline

- Left ventricular ejection fracture (LVEF) by Multiple gated acquisition scan (MUGA)≥
60%

- Practice effective contraceptive measures throughout study

- Verbal and written informed consent

- Prior therapy:

- Chemotherapy, minimum of 3 weeks and recovered from any treatment-related
toxicities (except for alopecia, and grade 1 neurotoxicity) prior to
registration

- Hormonal, discontinued prior to registration

- Radiation, minimum of 21 days and recovered from toxic effects prior to
registration

- Surgery, provided wound healing has occurred

Exclusion Criteria:

- History of significant cardiac disease unless well controlled

- Discontinuation from prior therapy due to cardiac toxicity

- Active or uncontrolled infections

- Serious illness or medical condition that could interfere with study participation

- History of any psychiatric condition that might impair understanding or compliance

- Documented history of diabetes mellitus

- Pregnant or breastfeeding females

- Unstable symptomatic brain metastases, that require steroid or that have required
radiation in the last 28 days

- Chronic systemic steroid use for cancer related condition

- History of allergic reactions

- Patients with cataract who are expected to undergo surgery within 6 months of
registration

- Use of drugs causing QT interval prolongation within 14 days prior to dosing

- Patients with clinically significant electrolyte imbalances