Inclusion Criteria:

- Primary diagnosis of high risk superficial bladder cancer according to EAU
guidelines (http://www.eortc.be/tools/bladdercalculator/),

- Having never been treated with other intravesical chemotherapeutic agents,

- And to consent to participate to the study

Exclusion Criteria:

- Concomitant tumours;

- Urinary tract infections (UTI);

- Altered function of the liver, kidneys and/or bone marrow;

- Major cardiovascular diseases;

- Life expectancy of less than 1 year;

- Intravesical chemotherapy in the previous 3 months or immunotherapy in the previous 6
months;

- Systemic chemotherapy and pelvic radiotherapy prior to TURB, and any condition that
in the judgment of the investigators would interfere with the subject's ability to
provide informed consent, comply with study instructions, place the subject at
increased risk, or which might confound interpretation of study results.