Working Memory Performance Among Childhood Brain Tumor Survivors Treated With Conformal Radiation Therapy: A Pilot Study
This is a cross-sectional controlled study of brain tumor survivors treated at St. Jude with
conformal radiation therapy. Brain tumor survivors (n= 50, solid tumor survivors (n=40), and
healthy sibling controls (n= 40) are evaluated once only with laboratory measures of
cognitive skills (working memory, episodic memory and estimated IQ) and parental
questionnaires (executive and adaptive functions). We also use buccal (cheek) swabs to
gather samples for DNA extraction. We hypothesize: brain tumor survivors will perform
significantly worse than solid tumor and healthy controls on measures of working memory,
working memory will correlate significantly with IQ, working memory will be associated with
parent report of executive functions and a specified genotype related to dopamine metabolism
will be associated with working memory impairment.
Observational Model: Case Control, Time Perspective: Cross-Sectional
Performance on experimental working memory measures (computerized self-ordered pointing tasks)
Collected during one time cross-sectional assessment.
Heather M Conklin, Ph.D.
St. Jude Children's Research Hospital
United States: Institutional Review Board
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