Inclusion Criteria:

- Females 18 through 30 years of age (must not have reached the 31st birthday)

- Written informed consent obtained from the volunteer

- Unless previously surgically sterilized, agrees to use an effective method of birth
control beginning 30 days before the first study injection and continuing through 60
days after the final study injection

- Must have a negative serum pregnancy test within 21 days of study entry and must not
be breast feeding

- Healthy by medical history and physical examination

- Seronegative for HPV-16 and HPV-18 antibody by ELISA within 21 days of study entry

- Cervical specimen negative for high-risk HPV DNA using the Digene Hybrid Capture® II
HPV test (high-risk types Probe B) within 21 days of study entry

- Normal Pap smear, using the Cytyc ThinPrep® Pap Test, within 21 days of study entry

- No evidence of anogenital HPV lesions or physical findings suggestive of other
gynaecologic pathogens on pelvic examination within 21 days of study entry

- Agrees to no other vaccines or experimental therapy until 30 days after the last
study injection

Exclusion Criteria:

- Acute illness or fever (oral temperature ≥ 99.5°F [37.5°C]) at start of the study

- History or clinical manifestations of significant medical or psychiatric disorder

- Use of immunosuppressive medication (inhaled and topical corticosteroids are
permitted) within the previous 90 days or history of immunodeficiency

- History of cancer

- History of alcohol or drug abuse within the past 2 years

- Abnormal laboratory blood values at screening. Other abnormal laboratory values in
the screening panel which in the opinion of the principal investigator are judged to
be clinically significant

- Receipt of immunoglobulin or blood products within 90 days prior to study entry

- History of abnormal Pap smear (other than a single prior report of ASCUS or
indeterminate Pap smear with a subsequent normal report)

- Genital herpes disease involving the cervix or with disease characterized on
examination or by history by extensive external lesions. Volunteers with a history of
recurrent genital herpes disease characterized by limited external lesions are
eligible to participate in the study.

- Positive tests for hepatitis C antibody, hepatitis B surface antigen, or HIV-1
antibody

- Any prior receipt of any vaccine (experimental or otherwise) for treatment or
prophylaxis of genital warts or other papillomavirus related condition. Any treatment
of genital warts or other papillomavirus related condition within 6 months of
randomization (local therapy for common skin and/or plantar warts is allowed)

- Previous administration of any components of the investigational vaccine

- Receipt of any experimental vaccine within 90 days prior to entry into this study

- Receipt of any experimental drug therapy within 30 days or five half-lives of the
experimental drug (if the half-life is known), whichever is longer