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Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia


N/A
30 Years
N/A
Open (Enrolling)
Female
Central Centrifugal Scarring Alopecia, Lichen Planopilaris, Discoid Lupus Erythematosus

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Trial Information

Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia


This is a single-center study, designed to evaluate the expression of Fas protein in skin
biopsies of patients with scarring alopecia including fourteen patients with central
centrifugal scarring alopecia (CCSA), three patients with lichen planopilaris (LP) and three
patients with discoid lupus erythematosus (DLE). Skin biopsies of five healthy participants
will be used as controls.


Inclusion Criteria:



- Participants ages 30 years or older with a biopsy- proven diagnosis of CCSA.

- Undergone standard of care treatment for CCSA by a WFUSM Dermatologist

- Women of child bearing age will be required to have a negative pregnancy test in
order to participate in the study

- Participants ages 30 years or older with a biopsy- proven diagnosis of LP.

- Participants ages 30 years or older with a biopsy- proven diagnosis of DLE.

- Healthy participants must be ages 30 years or older.

Exclusion Criteria:

- Age less than 30 years of age.

- Clinically evident bacterial or viral infection of the scalp.

- Pregnant or nursing woman of child-bearing potential.

- Participation in any other investigative research study involving study medication.

- Inability to return for the biopsy visit.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls.

Outcome Time Frame:

8 weeks

Safety Issue:

No

Principal Investigator

Amy McMichael, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Wake Forest University

Authority:

United States: Institutional Review Board

Study ID:

00000301

NCT ID:

NCT00691769

Start Date:

April 2006

Completion Date:

June 2013

Related Keywords:

  • Central Centrifugal Scarring Alopecia
  • Lichen Planopilaris
  • Discoid Lupus Erythematosus
  • Alopecia
  • Alopecia Areata
  • Cicatrix
  • Lichen Planus
  • Lupus Erythematosus, Discoid
  • Lupus Erythematosus, Systemic

Name

Location
Wake Forest University Health Sciences Dermatology Winston Salem, North Carolina  27157